What acid-base changes are typically seen during CPB and how are they managed?

• A. Alkalosis due to hemodilution; managed by adjusting perfusion temperature.
• B. No acid-base disturbance occurs during CPB.
• C. Can develop dilutional acidosis and lactate-driven metabolic acidosis; managed with perfusion adjustments and buffering.
• D. Respiratory alkalosis is the primary concern and is managed with ventilation changes.

Answer: (C)