Trimetaphan (Arfonad) works by direct:

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Multiple Choice

Trimetaphan (Arfonad) works by direct:

Explanation:
Direct ganglionic blockade. Trimetaphan blocks nicotinic receptors at autonomic ganglia, preventing transmission from preganglionic to postganglionic neurons. With this blockade, sympathetic outflow to the vessels is reduced, removing the usual vasoconstrictor input and causing direct vasodilation and a drop in blood pressure. It’s not acting as a beta-blocker, a calcium channel blocker, or a platelet inhibitor.

Direct ganglionic blockade. Trimetaphan blocks nicotinic receptors at autonomic ganglia, preventing transmission from preganglionic to postganglionic neurons. With this blockade, sympathetic outflow to the vessels is reduced, removing the usual vasoconstrictor input and causing direct vasodilation and a drop in blood pressure. It’s not acting as a beta-blocker, a calcium channel blocker, or a platelet inhibitor.

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