The maximum digoxin dose corresponds to which mg value?

• A. 1-2.5 mg
• B. 5-10 mg
• C. 0.1-0.25 mg
• D. 10-20 mg

Answer: (A)

Digoxin has a very narrow therapeutic window, so dosing is kept as low as possible while still achieving effect. The upper limit of what is considered safe for total, cumulative dosing is around 1–2 mg, with some older references noting up to about 2.5 mg. That makes the range of 1–2.5 mg the best match for the maximum dose.

In contrast, 0.1–0.25 mg is a common maintenance daily dose, not the maximum; values like 5–10 mg or 10–20 mg would greatly raise toxicity risk and are not used.