Pentothal is used during CPB for what purpose?

• A. Bronchodilation
• B. Neuroprotection
• C. Cholinesterase inhibition
• D. Hyperkalemia induction

Answer: (B)

Protecting brain tissue during CPB hinges on lowering the brain’s metabolic demands. Pentothal (thiopental) achieves this by reducing cerebral metabolic rate for oxygen and damping neuronal activity, which helps protect neurons during periods of reduced perfusion or potential ischemic stress. It can promote EEG burst suppression, further decreasing the brain’s need for oxygen and energy during bypass. This makes it a neuroprotective choice during CPB. It is not a bronchodilator, not a cholinesterase inhibitor, and it does not induce hyperkalemia.