Hetastarch (Hespan) is used to prevent third spacing. Which option best describes its use?

• A. Albumin
• B. Hetastarch (Hespan)
• C. Dextran
• D. Gelatin

Answer: (B)

Hetastarch works as a plasma volume expander by increasing circulating oncotic pressure, which pulls fluid from the interstitial space back into the intravascular compartment. This helps maintain intravascular volume and reduces fluid shifting into tissues (third spacing), particularly in settings like surgery or acute illness where capillary leak can occur. So naming Hetastarch itself describes its use for preventing third spacing. Other colloids like albumin, dextran, or gelatin can also expand plasma volume, but the statement specifies Hetastarch’s role, making it the best choice.