Amicar mechanism: Inhibits conversion of plasminogen to plasmin

• A. Inhibits platelet aggregation
• B. Activates plasmin
• C. Inhibits conversion of plasminogen to plasmin
• D. Inhibits thrombin

Answer: (C)

Amicar acts as an antifibrinolytic, protecting clots from being dissolved. It does this by blocking the activation of plasminogen into plasmin, and by interfering with plasmin’s ability to interact with fibrin. Since plasmin is the enzyme that breaks down fibrin, preventing its formation keeps clots stable and reduces bleeding. This mechanism is different from antiplatelet effects, which would inhibit platelet aggregation; it also does not promote plasmin activity or affect thrombin directly.